Assay Detail
Binding
CHEMBL652864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL1671613) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
The synthesis and biological activity of tetrahydroquinoline angiotensin II antagonists containing a substituted biphenyltetrazole group
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.95 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89143 | — | — | 1 | 8.22 |
| CHEMBL314859 | — | — | 1 | 8.15 |
| CHEMBL87603 | — | — | 1 | 8.10 |
| CHEMBL86858 | — | — | 1 | 7.70 |
| CHEMBL89846 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89143 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL314859 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL87603 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL86858 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL89846 | — | IC50 | = | 27.0 | nM | 7.57 |