Assay Detail
Binding
CHEMBL652865
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In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT1 and AT2 subtypes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.58 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313868 | — | — | 1 | 8.23 |
| CHEMBL323506 | — | — | 1 | 7.85 |
| CHEMBL321313 | — | — | 1 | 7.82 |
| CHEMBL321531 | — | — | 1 | 7.80 |
| CHEMBL96314 | — | — | 1 | 6.96 |
| CHEMBL96554 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313868 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL323506 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL321313 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL321531 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL96314 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL96554 | — | IC50 | = | 150.0 | nM | 6.82 |