Assay Detail
Functional
CHEMBL653016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro smooth muscle contraction activity in guinea pig ileum consists of two or three CCK receptor subtypes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N-methylated analogs of Ac[Nle28,31]CCK(26-33): synthesis, activity, and receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.26 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386682 | — | — | 1 | 9.30 |
| CHEMBL217236 | — | — | 1 | 9.05 |
| CHEMBL409529 | — | — | 1 | 8.85 |
| CHEMBL414592 | — | — | 1 | 8.46 |
| CHEMBL217609 | — | — | 1 | 8.40 |
| CHEMBL269185 | — | — | 1 | 7.58 |
| CHEMBL266839 | — | — | 1 | 7.43 |
| CHEMBL2370248 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386682 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL217236 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL409529 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL414592 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL217609 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL269185 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL266839 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2370248 | — | EC50 | = | 104.0 | nM | 6.98 |