Assay Detail
Binding
CHEMBL653018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.73 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 8.25 |
| CHEMBL116127 | — | — | 1 | 5.21 |
| CHEMBL3350851 | — | — | 1 | - |
| CHEMBL3350854 | — | — | 1 | - |
| CHEMBL3350855 | — | — | 1 | - |
| CHEMBL3350857 | — | — | 1 | - |
| CHEMBL3350852 | — | — | 1 | - |
| CHEMBL3350858 | — | — | 1 | - |
| CHEMBL3350853 | — | — | 1 | - |
| CHEMBL3350849 | — | — | 1 | - |
| CHEMBL3350850 | — | — | 1 | - |
| CHEMBL3350859 | — | — | 1 | - |
| CHEMBL3350856 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL116127 | — | IC50 | = | 6153.0 | nM | 5.21 |
| CHEMBL3350851 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350854 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350855 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350857 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350852 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350858 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350853 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350849 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350850 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350859 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350856 | — | IC50 | > | 10000.0 | nM | - |