Assay Detail
Functional
CHEMBL653065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Stomach |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-methylated analogs of Ac[Nle28,31]CCK(26-33): synthesis, activity, and receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.56 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386682 | — | — | 1 | 8.22 |
| CHEMBL217236 | — | — | 1 | 8.05 |
| CHEMBL414592 | — | — | 1 | 7.92 |
| CHEMBL409529 | — | — | 1 | 7.87 |
| CHEMBL217609 | — | — | 1 | 7.72 |
| CHEMBL2370248 | — | — | 1 | 7.27 |
| CHEMBL266839 | — | — | 1 | 6.85 |
| CHEMBL269185 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386682 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL217236 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL414592 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL409529 | — | EC50 | = | 13.5 | nM | 7.87 |
| CHEMBL217609 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2370248 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL266839 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL269185 | — | EC50 | = | 265.0 | nM | 6.58 |