Assay Detail
Functional
CHEMBL653108
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Tested for cytotoxicity against CH1 human ovarian cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CH1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.07 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17192 | — | — | 1 | 9.89 |
| CHEMBL608886 | — | — | 1 | 7.40 |
| CHEMBL293096 | — | — | 1 | 7.00 |
| CHEMBL291815 | — | — | 1 | 6.70 |
| CHEMBL418651 | — | — | 1 | 6.58 |
| CHEMBL292689 | — | — | 1 | 6.54 |
| CHEMBL302170 | — | — | 1 | 6.50 |
| CHEMBL433491 | — | — | 1 | 6.37 |
| CHEMBL293119 | — | — | 1 | 6.34 |
| CHEMBL54666 | — | — | 1 | 6.00 |
| CHEMBL433289 | — | — | 1 | 5.75 |
| CHEMBL300580 | — | — | 1 | 5.36 |
| CHEMBL60172 | — | — | 1 | 4.94 |
| CHEMBL291616 | — | — | 1 | 4.77 |
| CHEMBL416315 | — | — | 1 | 4.38 |
| CHEMBL301239 | — | — | 1 | 4.37 |
| CHEMBL60065 | — | — | 1 | 4.37 |
| CHEMBL300842 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17192 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL608886 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL293096 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL291815 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL418651 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL292689 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL302170 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL433491 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL293119 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL54666 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL433289 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL300580 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL60172 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL291616 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL416315 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL301239 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL60065 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL300842 | — | IC50 | > | 100000.0 | nM | - |