Assay Detail
Functional
CHEMBL653114
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Antagonistic effect against Angiotensin II receptor in rabbit aortic strip
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of angiotensin II antagonists with variations in position 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 9.24 | 9.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372778 | — | — | 1 | 9.53 |
| CHEMBL2372772 | — | — | 1 | 9.50 |
| CHEMBL2372774 | — | — | 1 | 9.42 |
| CHEMBL2372785 | — | — | 1 | 8.52 |
| CHEMBL938 | SARALASIN | 4.0 | 1 | - |
| CHEMBL2372783 | — | — | 1 | - |
| CHEMBL2372777 | — | — | 1 | - |
| CHEMBL2372775 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372778 | — | Kd | = | 0.2951 | nM | 9.53 |
| CHEMBL2372772 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL2372774 | — | Kd | = | 0.3802 | nM | 9.42 |
| CHEMBL2372785 | — | Kd | = | 3.02 | nM | 8.52 |
| CHEMBL938 | SARALASIN | Kd | = | 0.007943 | nM | - |
| CHEMBL2372783 | — | Kd | = | 0.008128 | nM | - |
| CHEMBL2372777 | — | Kd | = | 0.005129 | nM | - |
| CHEMBL2372775 | — | Kd | = | 0.006607 | nM | - |