Assay Detail
Functional
CHEMBL653115
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Antagonistic effect against Angiotensin II receptor in zona glomerulosa
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of angiotensin II antagonists with variations in position 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 9.32 | 10.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372777 | — | — | 1 | 10.39 |
| CHEMBL2372775 | — | — | 1 | 9.98 |
| CHEMBL2372774 | — | — | 1 | 9.93 |
| CHEMBL2372783 | — | — | 1 | 9.65 |
| CHEMBL938 | SARALASIN | 4.0 | 1 | 9.63 |
| CHEMBL2372778 | — | — | 1 | 8.61 |
| CHEMBL2372785 | — | — | 1 | 8.39 |
| CHEMBL2372772 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372777 | — | Kd | = | 0.04074 | nM | 10.39 |
| CHEMBL2372775 | — | Kd | = | 0.1045 | nM | 9.98 |
| CHEMBL2372774 | — | Kd | = | 0.1167 | nM | 9.93 |
| CHEMBL2372783 | — | Kd | = | 0.2244 | nM | 9.65 |
| CHEMBL938 | SARALASIN | Kd | = | 0.2323 | nM | 9.63 |
| CHEMBL2372778 | — | Kd | = | 2.432 | nM | 8.61 |
| CHEMBL2372785 | — | Kd | = | 4.055 | nM | 8.39 |
| CHEMBL2372772 | — | Kd | = | 10.02 | nM | 8.00 |