Assay Detail
Binding
CHEMBL653120
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Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membrane
7
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Uterus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Conformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptors antagonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.26 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274447 | — | — | 3 | 6.77 |
| CHEMBL311743 | — | — | 2 | 5.80 |
| CHEMBL311702 | — | — | 2 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274447 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL274447 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL274447 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL311743 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL311702 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL311702 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL311743 | — | IC50 | = | 340000.0 | nM | - |