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Assay Detail

CHEMBL653124

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [125I]- AII binding to rat uterine membrane angiotensin II receptor
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Angiotensin II receptor (CHEMBL2094112)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

1H-1,2,4-triazole angiostensin II receptor antagonists: qC-linkedq analogs of SC-50560
Reitz DB, Penick MA, Norton MB, Reinhard EJ, Olins GM, Corpus VM, Palomo MA, McGraw DE, McMahon EG
Bioorg Med Chem Lett (1994) 4 : 105 -110
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.33 8.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL85595 1 8.25
CHEMBL267555 1 8.02
CHEMBL12909 1 7.80
CHEMBL276406 1 7.40
CHEMBL12518 1 6.85
CHEMBL12598 1 6.62
CHEMBL12417 1 6.15
CHEMBL428889 1 5.75
CHEMBL12663 2 5.17
CHEMBL275680 1 4.54
CHEMBL415974 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL85595 IC50 = 5.6 nM 8.25
CHEMBL267555 IC50 = 9.5 nM 8.02
CHEMBL12909 IC50 = 16.0 nM 7.80
CHEMBL276406 IC50 = 40.0 nM 7.40
CHEMBL12518 IC50 = 140.0 nM 6.85
CHEMBL12598 IC50 = 240.0 nM 6.62
CHEMBL12417 IC50 = 710.0 nM 6.15
CHEMBL428889 IC50 = 1800.0 nM 5.75
CHEMBL12663 IC50 = 6700.0 nM 5.17
CHEMBL12663 IC50 = 12000.0 nM 4.92
CHEMBL275680 IC50 = 29000.0 nM 4.54
CHEMBL415974 IC50 = 32000.0 nM 4.50