Assay Detail

CHEMBL653128

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibition of [3H]diazepam binding to GABA-A central benzodiazepine receptor of rat brain homogenate

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Brain
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

6-(Alkylamino)-3-aryl-1,2,4-triazolo[3,4-a]phthalazines. A new class of benzodiazepine receptor ligands.

Tarzia G, Occelli E, Toja E, Barone D, Corsico N, Gallico L, Luzzani F.
J Med Chem (1988) 31 : 1115 -1123
PubMed 2836588 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.74	8.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL12	DIAZEPAM	4.0	1	8.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL12	DIAZEPAM	Ki	=	1.8	nM	8.74