Assay Detail
Functional
CHEMBL653161
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Agonistic activity against human Beta-3 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing Beta-3 adrenergic receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.41 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25133 | — | — | 1 | 7.92 |
| CHEMBL25254 | — | — | 1 | 7.16 |
| CHEMBL285899 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25133 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL25254 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL285899 | — | EC50 | = | 70.0 | nM | 7.16 |