Assay Detail
Binding
CHEMBL653175
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Compound was evaluated for inhibition against human carbonic anhydrase II
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.17 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69149 | — | — | 1 | 8.82 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 8.30 |
| CHEMBL51668 | — | — | 1 | 8.30 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL71000 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69149 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL51668 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL71000 | — | Ki | = | 15.0 | nM | 7.82 |