Assay Detail
Binding
CHEMBL653180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Calcineurin (CaN phosphatase)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Protein phosphatase 3 catalytic subunit alpha (CHEMBL4445) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.20 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407332 | — | — | 1 | 8.55 |
| CHEMBL266705 | — | — | 1 | 8.40 |
| CHEMBL268110 | — | — | 1 | 8.38 |
| CHEMBL405917 | — | — | 1 | 8.31 |
| CHEMBL412791 | — | — | 1 | 8.23 |
| CHEMBL65863 | — | — | 1 | 8.14 |
| CHEMBL264568 | — | — | 1 | 8.13 |
| CHEMBL275103 | — | — | 1 | 8.10 |
| CHEMBL305081 | — | — | 1 | 8.06 |
| CHEMBL431368 | — | — | 1 | 8.06 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 7.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407332 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL266705 | — | IC50 | = | 3.96 | nM | 8.40 |
| CHEMBL268110 | — | IC50 | = | 4.17 | nM | 8.38 |
| CHEMBL405917 | — | IC50 | = | 4.93 | nM | 8.31 |
| CHEMBL412791 | — | IC50 | = | 5.85 | nM | 8.23 |
| CHEMBL65863 | — | IC50 | = | 7.25 | nM | 8.14 |
| CHEMBL264568 | — | IC50 | = | 7.32 | nM | 8.13 |
| CHEMBL275103 | — | IC50 | = | 7.91 | nM | 8.10 |
| CHEMBL305081 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL431368 | — | IC50 | = | 8.65 | nM | 8.06 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 14.8 | nM | 7.83 |