Assay Detail
Binding
CHEMBL653181
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Inhibition of calcineurin phosphatase activity by the compound
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
32-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.34 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062134 | — | — | 1 | 8.09 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 7.96 |
| CHEMBL2062135 | — | — | 1 | 7.94 |
| CHEMBL2062133 | — | — | 1 | 7.10 |
| CHEMBL2052020 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062134 | — | IC50 | = | 8.21 | nM | 8.09 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL2062135 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL2062133 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2052020 | — | IC50 | = | 2500.0 | nM | 5.60 |