Assay Detail
Functional
CHEMBL653263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro multi drug resistance (MDR) reversal inhibitory activity against CCRF-CEM/VCR-1000 cell line
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM/VCR-1000 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Three-dimensional quantitative structure-activity relationship analysis of propafenone-type multidrug resistance modulators: influence of variable selection on test set predictivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 70 | 6.02 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96597 | — | — | 1 | 7.30 |
| CHEMBL147055 | — | — | 1 | 7.16 |
| CHEMBL344278 | — | — | 1 | 7.16 |
| CHEMBL344313 | — | — | 1 | 7.10 |
| CHEMBL145861 | — | — | 1 | 7.05 |
| CHEMBL148001 | — | — | 1 | 6.96 |
| CHEMBL357836 | — | — | 1 | 6.96 |
| CHEMBL144148 | — | — | 1 | 6.92 |
| CHEMBL146587 | — | — | 1 | 6.92 |
| CHEMBL318061 | — | — | 1 | 6.85 |
| CHEMBL343400 | — | — | 1 | 6.77 |
| CHEMBL341881 | — | — | 1 | 6.77 |
| CHEMBL95119 | — | — | 1 | 6.75 |
| CHEMBL148260 | — | — | 1 | 6.72 |
| CHEMBL147788 | — | — | 1 | 6.68 |
| CHEMBL146211 | — | — | 1 | 6.64 |
| CHEMBL445381 | — | — | 1 | 6.52 |
| CHEMBL96713 | — | — | 1 | 6.51 |
| CHEMBL146081 | — | — | 1 | 6.47 |
| CHEMBL344785 | — | — | 1 | 6.42 |
| CHEMBL146135 | — | — | 1 | 6.41 |
| CHEMBL148318 | — | — | 1 | 6.38 |
| CHEMBL420815 | — | — | 1 | 6.31 |
| CHEMBL147839 | — | — | 1 | 6.28 |
| CHEMBL357023 | — | — | 1 | 6.27 |
| CHEMBL146159 | — | — | 1 | 6.18 |
| CHEMBL146996 | — | — | 1 | 6.17 |
| CHEMBL319952 | — | — | 1 | 6.17 |
| CHEMBL422315 | — | — | 1 | 6.17 |
| CHEMBL343262 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96597 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL147055 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL344278 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL344313 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL145861 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL148001 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL357836 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL144148 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL146587 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL318061 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL343400 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL341881 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL95119 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL148260 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL147788 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL146211 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL445381 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL96713 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL146081 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL344785 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL146135 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL148318 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL420815 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL147839 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL357023 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL146159 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL319952 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL422315 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL146996 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL343262 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL148201 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL145168 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL147643 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL146558 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL357613 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL147724 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL93496 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL359190 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL149235 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL631 | PROPAFENONE | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL146084 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL147496 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL358299 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL356974 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL147865 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL96457 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL148196 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL148235 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL147852 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL142319 | — | IC50 | = | 2640.0 | nM | 5.58 |