Assay Detail
Functional
CHEMBL653287
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Compound was tested for anti-HIV-2 activity in CEM/TK- cell line.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-TK(-) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.14 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107184 | — | — | 1 | 7.12 |
| CHEMBL48229 | — | — | 1 | 5.16 |
| CHEMBL101500 | — | — | 1 | - |
| CHEMBL101415 | — | — | 1 | - |
| CHEMBL100915 | — | — | 1 | - |
| CHEMBL103996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107184 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL48229 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL101500 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL101415 | — | EC50 | = | 150000.0 | nM | - |
| CHEMBL100915 | — | EC50 | = | 160000.0 | nM | - |
| CHEMBL103996 | — | EC50 | > | 250000.0 | nM | - |