Assay Detail
Functional
CHEMBL653339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against CAOV-3 human tumor cell line.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caov-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro cytotoxicity of (RS)-20-desethyl-20-substituted camptothecin analogues
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.57 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.52 |
| CHEMBL301311 | — | — | 1 | 6.25 |
| CHEMBL354031 | — | — | 1 | 6.09 |
| CHEMBL168888 | — | — | 1 | 5.85 |
| CHEMBL167656 | — | — | 1 | 5.80 |
| CHEMBL169169 | — | — | 1 | 5.73 |
| CHEMBL166487 | — | — | 1 | 5.72 |
| CHEMBL355556 | — | — | 1 | 5.66 |
| CHEMBL166173 | — | — | 1 | 5.43 |
| CHEMBL355355 | — | — | 1 | 5.40 |
| CHEMBL354150 | — | — | 1 | 5.37 |
| CHEMBL353585 | — | — | 1 | 5.22 |
| CHEMBL432949 | — | — | 1 | 5.20 |
| CHEMBL352630 | — | — | 1 | 5.19 |
| CHEMBL352383 | — | — | 1 | 4.89 |
| CHEMBL355004 | — | — | 1 | 4.75 |
| CHEMBL167864 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL301311 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL354031 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL168888 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL167656 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL169169 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL166487 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL355556 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL166173 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL355355 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL354150 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL353585 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL432949 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL352630 | — | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL352383 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL355004 | — | IC50 | = | 17580.0 | nM | 4.75 |
| CHEMBL167864 | — | IC50 | = | 22480.0 | nM | 4.65 |