Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL653340

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was evaluated for in vitro antiproliferative activity against CAOV-3 human ovarian cancer cell line
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Caov-3
Confidence 1 — Organism
Curated By Intermediate

Target

Caov-3 cell line (CHEMBL614379)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring.
Jew SS, Kim MG, Kim HJ, Rho EY, Park HG, Kim JK, Han HJ, Lee H.
Bioorg Med Chem Lett (1998) 8 : 1797 -1800
PubMed 9873436 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.21 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL301393 1 8.52
CHEMBL50835 1 8.40
CHEMBL50418 1 8.00
CHEMBL300396 1 7.62
CHEMBL276820 1 7.50
CHEMBL52226 1 7.06
CHEMBL52910 1 7.04
CHEMBL51495 1 6.32
CHEMBL301311 1 6.25
CHEMBL299423 1 5.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL301393 IC50 = 3.0 nM 8.52
CHEMBL50835 IC50 = 4.0 nM 8.40
CHEMBL50418 IC50 = 10.0 nM 8.00
CHEMBL300396 IC50 = 24.0 nM 7.62
CHEMBL276820 IC50 = 32.0 nM 7.50
CHEMBL52226 IC50 = 87.0 nM 7.06
CHEMBL52910 IC50 = 91.0 nM 7.04
CHEMBL51495 IC50 = 483.0 nM 6.32
CHEMBL301311 IC50 = 560.0 nM 6.25
CHEMBL299423 IC50 = 3762.0 nM 5.42