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Assay Detail

CHEMBL653341

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Functional
In vitro cytotoxicity against human tumor cell line CAOV-3
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Caov-3
Confidence 1 — Organism
Curated By Expert

Target

Caov-3 cell line (CHEMBL614379)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues.
Jew S, Kim HJ, Kim MG, Roh EY, Hong CI, Kim JK, Lee JH, Lee H, Park H.
Bioorg Med Chem Lett (1999) 9 : 3203 -3206
PubMed 10576688 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.06 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL109521 1 5.82
CHEMBL109188 1 5.70
CHEMBL109029 1 5.63
CHEMBL441645 1 5.46
CHEMBL111658 1 5.18
CHEMBL107773 1 5.15
CHEMBL109103 1 5.15
CHEMBL322998 1 4.66
CHEMBL108027 1 4.48
CHEMBL109181 1 4.21
CHEMBL108508 1 4.20
CHEMBL322309 1 -
CHEMBL420670 1 -
CHEMBL321011 1 -
CHEMBL432606 1 -
CHEMBL65 CAMPTOTHECIN -1.0 1 -
CHEMBL419007 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL109521 IC50 = 1510.0 nM 5.82
CHEMBL109188 IC50 = 2000.0 nM 5.70
CHEMBL109029 IC50 = 2320.0 nM 5.63
CHEMBL441645 IC50 = 3500.0 nM 5.46
CHEMBL111658 IC50 = 6570.0 nM 5.18
CHEMBL107773 IC50 = 7120.0 nM 5.15
CHEMBL109103 IC50 = 7120.0 nM 5.15
CHEMBL322998 IC50 = 21890.0 nM 4.66
CHEMBL108027 IC50 = 33000.0 nM 4.48
CHEMBL109181 IC50 = 62030.0 nM 4.21
CHEMBL108508 IC50 = 63000.0 nM 4.20
CHEMBL322309 IC50 = 400000.0 nM -
CHEMBL420670 IC50 = 1700000.0 nM -
CHEMBL321011 IC50 > 100000.0 nM -
CHEMBL432606 IC50 > 100000.0 nM -
CHEMBL65 CAMPTOTHECIN IC50 = 2900000.0 nM -
CHEMBL419007 IC50 = 140000000.0 nM -