Assay Detail
Functional
CHEMBL653386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to inhibit cartilage breakdown by using 1L-1beta stimulated bovine nasal cartilage assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Tissue | Nasal cartilage |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Inhibition of cartilage breakdown by isothiazolones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.12 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417537 | — | — | 1 | 5.52 |
| CHEMBL45152 | — | — | 1 | 5.52 |
| CHEMBL316658 | — | — | 1 | 5.52 |
| CHEMBL98386 | — | — | 1 | 5.44 |
| CHEMBL318367 | — | — | 1 | 5.43 |
| CHEMBL98663 | — | — | 1 | 5.30 |
| CHEMBL100470 | — | — | 1 | 5.05 |
| CHEMBL48213 | — | — | 1 | 5.00 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 4.89 |
| CHEMBL95284 | — | — | 1 | 4.87 |
| CHEMBL318449 | — | — | 1 | 4.77 |
| CHEMBL317000 | — | — | 1 | 4.74 |
| CHEMBL99137 | — | — | 1 | 4.55 |
| CHEMBL154 | NAPROXEN | 4.0 | 1 | - |
| CHEMBL95830 | — | — | 1 | - |
| CHEMBL1719803 | — | — | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL38502 | — | — | 1 | - |
| CHEMBL98300 | — | — | 1 | - |
| CHEMBL99594 | — | — | 1 | - |
| CHEMBL82970 | SALICYLANILIDE | -1.0 | 1 | - |
| CHEMBL99313 | — | — | 1 | - |
| CHEMBL1440 | TETRACYCLINE | 4.0 | 1 | - |
| CHEMBL320007 | — | — | 1 | - |
| CHEMBL316825 | — | — | 1 | - |
| CHEMBL327502 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417537 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL45152 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL316658 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL98386 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL318367 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL98663 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL100470 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL48213 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL51085 | EBSELEN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL95284 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL318449 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL317000 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL99137 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL154 | NAPROXEN | IC50 | > | 30000.0 | nM | - |
| CHEMBL95830 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1719803 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 30000.0 | nM | - |
| CHEMBL38502 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL98300 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL99594 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL82970 | SALICYLANILIDE | IC50 | > | 30000.0 | nM | - |
| CHEMBL99313 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1440 | TETRACYCLINE | IC50 | > | 30000.0 | nM | - |
| CHEMBL320007 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL316825 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL327502 | — | IC50 | > | 30000.0 | nM | - |