Assay Detail

CHEMBL653487

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibitory activity against IL-2 induced proliferation in mouse CTLL cells

ChEMBL ↗

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Target

CTLL (CHEMBL614565) ↗

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Primary target CTLL

CHEMBL614565

Anchored from Assay target.

Protein identity CTLL

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	CTLL
Confidence	1 — Organism
Curated By	Intermediate

Target

CTLL (CHEMBL614565) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Mapping the kinase domain of Janus Kinase 3.

Adams C, Aldous DJ, Amendola S, Bamborough P, Bright C, Crowe S, Eastwood P, Fenton G, Foster M, Harrison TK, King S, Lai J, Lawrence C, Letallec JP, McCarthy C, Moorcroft N, Page K, Rao S, Redford J, Sadiq S, Smith K, Souness JE, Thurairatnam S, Vine M, Wyman B.
Bioorg Med Chem Lett (2003) 13 : 3105 -3110
PubMed 12941344 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.64	5.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL320646	—	—	1	5.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL320646	—	IC50	=	2300.0	nM	5.64