Assay Detail
Binding
CHEMBL653507
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Inhibition of human Beta-secretase 1
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Green tea catechins as a BACE1 (beta-secretase) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.15 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338988 | — | — | 1 | 5.80 |
| CHEMBL126079 | — | — | 1 | 5.75 |
| CHEMBL130415 | — | — | 1 | 5.62 |
| CHEMBL125743 | GALLOCATECHIN | — | 1 | 5.60 |
| CHEMBL126142 | — | — | 1 | 5.35 |
| CHEMBL129451 | (-)-CATECHINGALLATE | — | 1 | 5.22 |
| CHEMBL129482 | (+)-EPICATECHIN | 2.0 | 2 | 4.64 |
| CHEMBL200715 | (-)-CATECHIN | — | 1 | 4.52 |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | 4.46 |
| CHEMBL2303749 | — | — | 1 | - |
| CHEMBL127911 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338988 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL126079 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL130415 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL125743 | GALLOCATECHIN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL126142 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL129451 | (-)-CATECHINGALLATE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL129482 | (+)-EPICATECHIN | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL129482 | (+)-EPICATECHIN | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL200715 | (-)-CATECHIN | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL311498 | CIANIDANOL | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2303749 | — | IC50 | > | 160000.0 | nM | - |
| CHEMBL127911 | — | IC50 | > | 160000.0 | nM | - |