Assay Detail
Functional
CHEMBL653553
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Ability to inhibit 3H substance P binding to bovine retina was evaluated
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Tissue | Retina |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
IRL 2500: A potent ETB selective endothelin antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.90 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305615 | — | — | 1 | 6.10 |
| CHEMBL439759 | — | — | 1 | 5.70 |
| CHEMBL72410 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305615 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL439759 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL72410 | — | IC50 | > | 10000.0 | nM | - |