Assay Detail
Binding
CHEMBL653555
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Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Benzodiazepines as potent and selective bradykinin B1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.48 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1253497 | — | — | 1 | 8.72 |
| CHEMBL1744083 | — | — | 1 | 8.32 |
| CHEMBL1744084 | — | — | 1 | 8.10 |
| CHEMBL1744082 | — | — | 1 | 7.61 |
| CHEMBL1744085 | — | — | 1 | 7.19 |
| CHEMBL52498 | — | — | 1 | 6.79 |
| CHEMBL1788318 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1253497 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1744083 | — | IC50 | = | 4.83 | nM | 8.32 |
| CHEMBL1744084 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1744082 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL1744085 | — | IC50 | = | 64.5 | nM | 7.19 |
| CHEMBL52498 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL1788318 | — | IC50 | = | 2200.0 | nM | 5.66 |