Assay Detail
Binding
CHEMBL653724
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscle
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Muscle tissue |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095229) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Dimeric 1,4-dihydropyridines as calcium channel antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 10.37 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286157 | — | — | 1 | 11.00 |
| CHEMBL286598 | — | — | 1 | 10.77 |
| CHEMBL37402 | — | — | 1 | 10.66 |
| CHEMBL37899 | — | — | 1 | 10.52 |
| CHEMBL204616 | — | — | 1 | 10.48 |
| CHEMBL35368 | — | — | 1 | 10.35 |
| CHEMBL1099207 | — | — | 1 | 10.34 |
| CHEMBL285868 | — | — | 1 | 10.30 |
| CHEMBL475534 | NITRENDIPINE | 3.0 | 1 | 9.82 |
| CHEMBL35123 | — | — | 1 | 9.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286157 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL286598 | — | IC50 | = | 0.017 | nM | 10.77 |
| CHEMBL37402 | — | IC50 | = | 0.022 | nM | 10.66 |
| CHEMBL37899 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL204616 | — | IC50 | = | 0.033 | nM | 10.48 |
| CHEMBL35368 | — | IC50 | = | 0.045 | nM | 10.35 |
| CHEMBL1099207 | — | IC50 | = | 0.046 | nM | 10.34 |
| CHEMBL285868 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL475534 | NITRENDIPINE | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL35123 | — | IC50 | = | 0.39 | nM | 9.41 |