Assay Detail
Binding
CHEMBL653726
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscle
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Muscle tissue |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095229) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Crystal structures and pharmacologic activities of 1,4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nisoldipine) series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.72 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317044 | — | — | 1 | 10.89 |
| CHEMBL441428 | — | — | 1 | 10.82 |
| CHEMBL103806 | — | — | 1 | 10.57 |
| CHEMBL321999 | — | — | 1 | 9.85 |
| CHEMBL105444 | — | — | 1 | 9.60 |
| CHEMBL319033 | — | — | 1 | 8.82 |
| CHEMBL102498 | — | — | 1 | 8.64 |
| CHEMBL318521 | — | — | 1 | 8.55 |
| CHEMBL102907 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317044 | — | IC50 | = | 0.013 | nM | 10.89 |
| CHEMBL441428 | — | IC50 | = | 0.015 | nM | 10.82 |
| CHEMBL103806 | — | IC50 | = | 0.027 | nM | 10.57 |
| CHEMBL321999 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL105444 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL319033 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL102498 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL318521 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL102907 | — | IC50 | = | 0.0081 | nM | - |