Assay Detail
Binding
CHEMBL653843
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Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Cystic fibrosis transmembrane conductance regulator (CHEMBL3992) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 22 | 4.25 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85369 | — | — | 1 | 4.64 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 4.40 |
| CHEMBL81937 | — | — | 1 | 4.31 |
| CHEMBL82279 | — | — | 1 | 4.30 |
| CHEMBL81938 | — | — | 1 | 4.23 |
| CHEMBL313066 | — | — | 1 | 4.21 |
| CHEMBL312783 | — | — | 1 | 4.19 |
| CHEMBL82409 | — | — | 1 | 4.18 |
| CHEMBL82459 | — | — | 1 | 4.14 |
| CHEMBL84391 | — | — | 1 | 4.14 |
| CHEMBL309381 | — | — | 1 | 4.00 |
| CHEMBL83374 | — | — | 1 | - |
| CHEMBL82153 | — | — | 1 | - |
| CHEMBL83050 | — | — | 1 | - |
| CHEMBL313739 | — | — | 1 | - |
| CHEMBL431213 | — | — | 1 | - |
| CHEMBL310410 | — | — | 1 | - |
| CHEMBL309839 | — | — | 1 | - |
| CHEMBL83758 | — | — | 1 | - |
| CHEMBL85504 | — | — | 1 | - |
| CHEMBL310408 | — | — | 1 | - |
| CHEMBL84000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85369 | — | Kd | = | 23000.0 | nM | 4.64 |
| CHEMBL44 | GENISTEIN | Kd | = | 40000.0 | nM | 4.40 |
| CHEMBL81937 | — | Kd | = | 49000.0 | nM | 4.31 |
| CHEMBL82279 | — | Kd | = | 50000.0 | nM | 4.30 |
| CHEMBL81938 | — | Kd | = | 59000.0 | nM | 4.23 |
| CHEMBL313066 | — | Kd | = | 61000.0 | nM | 4.21 |
| CHEMBL312783 | — | Kd | = | 64000.0 | nM | 4.19 |
| CHEMBL82409 | — | Kd | = | 66000.0 | nM | 4.18 |
| CHEMBL82459 | — | Kd | = | 73000.0 | nM | 4.14 |
| CHEMBL84391 | — | Kd | = | 72000.0 | nM | 4.14 |
| CHEMBL309381 | — | Kd | = | 100000.0 | nM | 4.00 |
| CHEMBL83374 | — | Kd | = | 115000.0 | nM | - |
| CHEMBL82153 | — | Kd | = | 110000.0 | nM | - |
| CHEMBL83050 | — | Kd | > | 300000.0 | nM | - |
| CHEMBL313739 | — | Kd | = | 118000.0 | nM | - |
| CHEMBL431213 | — | Kd | > | 300000.0 | nM | - |
| CHEMBL310410 | — | Kd | = | 177000.0 | nM | - |
| CHEMBL309839 | — | Kd | > | 300000.0 | nM | - |
| CHEMBL83758 | — | Kd | = | 220000.0 | nM | - |
| CHEMBL85504 | — | Kd | = | 147000.0 | nM | - |
| CHEMBL310408 | — | Kd | = | 104000.0 | nM | - |
| CHEMBL84000 | — | Kd | = | 357000.0 | nM | - |