Assay Detail
Toxicity
CHEMBL653850
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In vitro toxicity against colony forming unit granulocyte macrophage (CFU-GM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CFU-GM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
An enantiospecific synthesis of the human cytomegalovirus antiviral agent [(R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.37 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 4.72 |
| CHEMBL413540 | — | — | 1 | 4.02 |
| CHEMBL282358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL413540 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL282358 | — | IC50 | = | 280000.0 | nM | - |