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Assay Detail

CHEMBL653916

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Functional
In vitro cytotoxicity against CH1 ovarian cells using the sulforhodamine B(SRB) assay.
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CH1
Confidence 1 — Organism
Curated By Expert

Target

CH1 (CHEMBL614455) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.
Perry PJ, Reszka AP, Wood AA, Read MA, Gowan SM, Dosanjh HS, Trent JO, Jenkins TC, Kelland LR, Neidle S.
J Med Chem (1998) 41 : 4873 -4884
PubMed 9822556 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 50 5.79 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL345004 — — 1 7.72
CHEMBL300584 — — 1 7.40
CHEMBL359443 — — 1 6.58
CHEMBL141831 — — 1 6.58
CHEMBL144664 — — 1 6.50
CHEMBL144088 — — 1 6.44
CHEMBL356077 — — 1 6.43
CHEMBL144848 — — 1 6.38
CHEMBL144617 — — 1 6.24
CHEMBL14832 — — 1 5.98
CHEMBL144999 — — 1 5.96
CHEMBL423017 — — 1 5.95
CHEMBL343238 — — 1 5.95
CHEMBL444340 — — 1 5.89
CHEMBL144756 — — 1 5.89
CHEMBL144984 — — 1 5.87
CHEMBL144134 — — 1 5.87
CHEMBL422120 — — 1 5.85
CHEMBL146602 — — 1 5.80
CHEMBL322704 — — 1 5.78
CHEMBL145311 — — 1 5.78
CHEMBL144219 — — 1 5.78
CHEMBL110044 — — 1 5.77
CHEMBL145490 — — 1 5.76
CHEMBL444347 — — 1 5.75
CHEMBL142900 — — 1 5.75
CHEMBL144757 — — 1 5.75
CHEMBL107707 — — 1 5.73
CHEMBL146111 — — 1 5.72
CHEMBL109617 — — 1 5.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL345004 — IC50 = 19.0 nM 7.72
CHEMBL300584 — IC50 = 40.0 nM 7.40
CHEMBL141831 — IC50 = 260.0 nM 6.58
CHEMBL359443 — IC50 = 260.0 nM 6.58
CHEMBL144664 — IC50 = 320.0 nM 6.50
CHEMBL144088 — IC50 = 360.0 nM 6.44
CHEMBL356077 — IC50 = 370.0 nM 6.43
CHEMBL144848 — IC50 = 420.0 nM 6.38
CHEMBL144617 — IC50 = 580.0 nM 6.24
CHEMBL14832 — IC50 = 1050.0 nM 5.98
CHEMBL144999 — IC50 = 1100.0 nM 5.96
CHEMBL423017 — IC50 = 1130.0 nM 5.95
CHEMBL343238 — IC50 = 1120.0 nM 5.95
CHEMBL144756 — IC50 = 1300.0 nM 5.89
CHEMBL444340 — IC50 = 1280.0 nM 5.89
CHEMBL144984 — IC50 = 1350.0 nM 5.87
CHEMBL144134 — IC50 = 1350.0 nM 5.87
CHEMBL422120 — IC50 = 1400.0 nM 5.85
CHEMBL146602 — IC50 = 1600.0 nM 5.80
CHEMBL322704 — IC50 = 1650.0 nM 5.78
CHEMBL145311 — IC50 = 1650.0 nM 5.78
CHEMBL144219 — IC50 = 1680.0 nM 5.78
CHEMBL110044 — IC50 = 1700.0 nM 5.77
CHEMBL145490 — IC50 = 1750.0 nM 5.76
CHEMBL144757 — IC50 = 1800.0 nM 5.75
CHEMBL142900 — IC50 = 1800.0 nM 5.75
CHEMBL444347 — IC50 = 1800.0 nM 5.75
CHEMBL107707 — IC50 = 1850.0 nM 5.73
CHEMBL146111 — IC50 = 1900.0 nM 5.72
CHEMBL109617 — IC50 = 1900.0 nM 5.72
CHEMBL144827 — IC50 = 1950.0 nM 5.71
CHEMBL144386 — IC50 = 1950.0 nM 5.71
CHEMBL111417 — IC50 = 2000.0 nM 5.70
CHEMBL344274 — IC50 = 2050.0 nM 5.69
CHEMBL144334 — IC50 = 2100.0 nM 5.68
CHEMBL344072 — IC50 = 2250.0 nM 5.65
CHEMBL34683 — IC50 = 3150.0 nM 5.50
CHEMBL89250 — IC50 = 3150.0 nM 5.50
CHEMBL109890 — IC50 = 4300.0 nM 5.37
CHEMBL89977 — IC50 = 4400.0 nM 5.36
CHEMBL143452 — IC50 = 4500.0 nM 5.35
CHEMBL91163 — IC50 = 4600.0 nM 5.34
CHEMBL145575 — IC50 = 5300.0 nM 5.28
CHEMBL33618 — IC50 = 5900.0 nM 5.23
CHEMBL144303 — IC50 = 6300.0 nM 5.20
CHEMBL91898 — IC50 = 7500.0 nM 5.12
CHEMBL33505 — IC50 = 14000.0 nM 4.85
CHEMBL144208 — IC50 = 21500.0 nM 4.67
CHEMBL343445 — IC50 = 49000.0 nM 4.31
CHEMBL144411 — IC50 > 25000.0 nM -