Assay Detail
Binding
CHEMBL654001
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Tested for the ability to inhibit Beta-lactamase of Bacillus cereus (class A enzyme) with 10 minutes pre-incubation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus cereus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and -lactamase inhibitory evaluation of novel 6-halo-2-chloromethyl-2-methylpenam-3-carboxylic acids and their sulfones and 6-halo-2-mercaptobenzothiazolylmethyl-2-methylpenam-3-carboxylic acids
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.38 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 4.60 |
| CHEMBL304479 | — | — | 1 | 4.16 |
| CHEMBL64818 | — | — | 1 | - |
| CHEMBL293223 | — | — | 1 | - |
| CHEMBL60215 | — | — | 1 | - |
| CHEMBL64868 | — | — | 1 | - |
| CHEMBL293384 | — | — | 1 | - |
| CHEMBL292938 | — | — | 1 | - |
| CHEMBL300570 | — | — | 1 | - |
| CHEMBL61263 | — | — | 1 | - |
| CHEMBL304855 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403 | SULBACTAM | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL304479 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL64818 | — | IC50 | > | 3000000.0 | nM | - |
| CHEMBL293223 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL60215 | — | IC50 | > | 5000000.0 | nM | - |
| CHEMBL64868 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL293384 | — | IC50 | > | 5000000.0 | nM | - |
| CHEMBL292938 | — | IC50 | > | 5000000.0 | nM | - |
| CHEMBL300570 | — | IC50 | > | 5000000.0 | nM | - |
| CHEMBL61263 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL304855 | — | IC50 | = | 200000.0 | nM | - |