Assay Detail
Functional
CHEMBL654080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of degradation of tyrosine kinase pp60src by Calpain 1 in human platelets
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.05 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423112 | — | — | 1 | 6.16 |
| CHEMBL80605 | — | — | 1 | 6.16 |
| CHEMBL77784 | — | — | 1 | 6.10 |
| CHEMBL80933 | — | — | 1 | 6.00 |
| CHEMBL310855 | — | — | 1 | 5.85 |
| CHEMBL281874 | — | — | 1 | - |
| CHEMBL26631 | — | — | 1 | - |
| CHEMBL80903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423112 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL80605 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL77784 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL80933 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL310855 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL281874 | — | IC50 | = | - | nM | - |
| CHEMBL26631 | — | IC50 | = | - | nM | - |
| CHEMBL80903 | — | IC50 | = | - | nM | - |