Assay Detail
Binding
CHEMBL654082
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Inhibitory activity against on human calpain 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel dual inhibitors of calpain and lipid peroxidation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.32 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333995 | — | — | 1 | 7.70 |
| CHEMBL3706732 | — | — | 1 | 7.65 |
| CHEMBL3706727 | — | — | 1 | 7.09 |
| CHEMBL123621 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333995 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3706732 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL3706727 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL123621 | — | IC50 | = | 147.0 | nM | 6.83 |