Assay Detail
Functional
CHEMBL654121
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Inhibition of p24 antigen formation in infected C8166-cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.03 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338099 | — | — | 1 | 8.30 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.70 |
| CHEMBL434441 | — | — | 1 | 7.52 |
| CHEMBL124248 | — | — | 1 | 7.10 |
| CHEMBL127427 | — | — | 1 | 6.80 |
| CHEMBL125205 | — | — | 1 | 6.47 |
| CHEMBL435216 | — | — | 1 | 6.42 |
| CHEMBL338339 | — | — | 1 | 5.96 |
| CHEMBL125084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338099 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL434441 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL124248 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL127427 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL125205 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL435216 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL338339 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL125084 | — | EC50 | < | 80.0 | nM | - |