Assay Detail
Functional
CHEMBL654154
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In vitro membrane potential on murine beta-TC3 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.13 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48923 | — | — | 1 | 6.30 |
| CHEMBL301508 | — | — | 1 | 6.05 |
| CHEMBL50179 | — | — | 1 | 5.40 |
| CHEMBL298075 | — | — | 1 | 4.89 |
| CHEMBL48197 | — | — | 1 | 4.72 |
| CHEMBL48433 | — | — | 1 | 4.44 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.11 |
| CHEMBL50968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48923 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL301508 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL50179 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL298075 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL48197 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL48433 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 77400.0 | nM | 4.11 |
| CHEMBL50968 | — | IC50 | > | 100000.0 | nM | - |