Assay Detail
Binding
CHEMBL654175
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Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept for potent calcitonin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.42 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2369895 | — | — | 1 | 10.64 |
| CHEMBL2369912 | — | — | 1 | 10.30 |
| CHEMBL2369907 | — | — | 1 | 10.29 |
| CHEMBL2369886 | — | — | 1 | 10.16 |
| CHEMBL2369915 | — | — | 1 | 10.16 |
| CHEMBL2369893 | — | — | 1 | 9.25 |
| CHEMBL2369897 | — | — | 1 | 8.28 |
| CHEMBL2369892 | — | — | 1 | 7.37 |
| CHEMBL2369899 | — | — | 1 | 6.71 |
| CHEMBL2369905 | — | — | 1 | 6.40 |
| CHEMBL2304022 | — | — | 1 | 5.91 |
| CHEMBL2369904 | — | — | 1 | 5.59 |
| CHEMBL2369898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2369895 | — | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL2369912 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL2369907 | — | Ki | = | 0.051 | nM | 10.29 |
| CHEMBL2369886 | — | Ki | = | 0.069 | nM | 10.16 |
| CHEMBL2369915 | — | Ki | = | 0.069 | nM | 10.16 |
| CHEMBL2369893 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL2369897 | — | Ki | = | 5.28 | nM | 8.28 |
| CHEMBL2369892 | — | Ki | = | 42.5 | nM | 7.37 |
| CHEMBL2369899 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL2369905 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL2304022 | — | Ki | = | 1229.0 | nM | 5.91 |
| CHEMBL2369904 | — | Ki | = | 2569.0 | nM | 5.59 |
| CHEMBL2369898 | — | Ki | > | 2500.0 | nM | - |