Assay Detail
Functional
CHEMBL654294
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Inhibition of 10e-9 M aldosterone activity in CV-1 cells expressing mineralocorticoid receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New steroidal diazo ketones as potential photoaffinity labeling reagents for the mineralocorticoid receptor: synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.58 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.52 |
| CHEMBL2112397 | — | — | 1 | 6.16 |
| CHEMBL2112398 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103 | PROGESTERONE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2112397 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2112398 | — | IC50 | = | 900.0 | nM | 6.05 |