Assay Detail
Functional
CHEMBL654334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity to reduce the amount of p24 in C8166 cells infected with efavirenz resistance strain K103R, V179D, and P225H.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.08 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82106 | — | — | 1 | 6.58 |
| CHEMBL83800 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82106 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL83800 | — | EC50 | = | 2600.0 | nM | 5.58 |