Assay Detail
Functional
CHEMBL654335
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity to reduce the amount of p24 in C8166 cells infected with efavirenz resistance strain carrying mutations HIV-1 K103N-Y181C
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.19 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85059 | — | — | 1 | 6.19 |
| CHEMBL315349 | — | — | 1 | 6.19 |
| CHEMBL84217 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85059 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL315349 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL84217 | — | EC50 | > | 100000.0 | nM | - |