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Assay Detail

CHEMBL654354

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Polymerizing activity of tubulin in glutamate against bovine brain tubulin homogenate was measured at 0.8M concentrations
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Bos taurus
Tissue Brain
Confidence 1 — Organism
Curated By Expert

Target

Bos taurus (CHEMBL613489)
Type ORGANISM
Organism Bos taurus

Publication

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).
Kingston DG, Chaudhary AG, Chordia MD, Gharpure M, Gunatilaka AA, Higgs PI, Rimoldi JM, Samala L, Jagtap PG, Giannakakou P, Jiang YQ, Lin CM, Hamel E, Long BH, Fairchild CR, Johnston KA.
J Med Chem (1998) 41 : 3715 -3726
PubMed 9733497 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.54 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL333538 1 5.92
CHEMBL123431 1 5.92
CHEMBL410880 1 5.80
CHEMBL333740 1 5.70
CHEMBL334077 1 5.58
CHEMBL332080 1 5.57
CHEMBL331065 1 5.54
CHEMBL339660 1 5.51
CHEMBL340906 1 5.51
CHEMBL334075 1 5.51
CHEMBL412803 1 5.51
CHEMBL415835 1 5.40
CHEMBL123018 1 5.33
CHEMBL333526 1 5.33
CHEMBL124777 1 5.29
CHEMBL331740 1 5.17
CHEMBL341145 1 -
CHEMBL408087 1 -
CHEMBL331608 1 -
CHEMBL331998 1 -
CHEMBL122465 1 -
CHEMBL341501 1 -
CHEMBL441377 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL333538 IC50 = 1200.0 nM 5.92
CHEMBL123431 IC50 = 1200.0 nM 5.92
CHEMBL410880 IC50 = 1600.0 nM 5.80
CHEMBL333740 IC50 = 2000.0 nM 5.70
CHEMBL334077 IC50 = 2600.0 nM 5.58
CHEMBL332080 IC50 = 2700.0 nM 5.57
CHEMBL331065 IC50 = 2900.0 nM 5.54
CHEMBL339660 IC50 = 3100.0 nM 5.51
CHEMBL340906 IC50 = 3100.0 nM 5.51
CHEMBL334075 IC50 = 3100.0 nM 5.51
CHEMBL412803 IC50 = 3100.0 nM 5.51
CHEMBL415835 IC50 = 4000.0 nM 5.40
CHEMBL123018 IC50 = 4700.0 nM 5.33
CHEMBL333526 IC50 = 4700.0 nM 5.33
CHEMBL124777 IC50 = 5100.0 nM 5.29
CHEMBL331740 IC50 = 6700.0 nM 5.17
CHEMBL341145 IC50 > 8900.0 nM -
CHEMBL408087 IC50 > 8900.0 nM -
CHEMBL331608 IC50 > 8900.0 nM -
CHEMBL331998 IC50 > 8900.0 nM -
CHEMBL122465 IC50 > 8900.0 nM -
CHEMBL341501 IC50 > 8900.0 nM -
CHEMBL441377 IC50 > 8900.0 nM -