Assay Detail
Binding
CHEMBL654393
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Inhibitory activity against Butyrylcholinesterase (BChE)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.28 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443499 | — | — | 1 | 5.50 |
| CHEMBL422905 | — | — | 1 | 5.26 |
| CHEMBL173955 | — | — | 1 | 5.07 |
| CHEMBL1115 | PYRIDOSTIGMINE | 4.0 | 1 | - |
| CHEMBL173694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443499 | — | Ki | = | 3140.0 | nM | 5.50 |
| CHEMBL422905 | — | Ki | = | 5530.01 | nM | 5.26 |
| CHEMBL173955 | — | Ki | = | 8510.01 | nM | 5.07 |
| CHEMBL1115 | PYRIDOSTIGMINE | Ki | = | 114000.0 | nM | - |
| CHEMBL173694 | — | Ki | = | 1380010.0 | nM | - |