Assay Detail
Functional
CHEMBL654429
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Tested for cytotoxicity against C38 cell lines measured by MAT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MC-38 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of 9-hydroxy-5-methyl-(and 5,6-dimethyl)-6H-pyrido[4,3-b]carbazole-1-N- [(dialkylamino)alkyl]carboxamides, a new promising series of antitumor olivacine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.68 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303482 | — | — | 1 | 8.16 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.00 |
| CHEMBL263710 | — | — | 1 | 7.96 |
| CHEMBL309219 | — | — | 1 | 7.96 |
| CHEMBL311374 | — | — | 1 | 7.72 |
| CHEMBL84183 | — | — | 1 | 7.66 |
| CHEMBL24078 | ELLIPTINIUM ACETATE | 2.0 | 1 | 7.42 |
| CHEMBL419844 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303482 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL263710 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL309219 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL311374 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL84183 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL24078 | ELLIPTINIUM ACETATE | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL419844 | — | IC50 | = | 259.0 | nM | 6.59 |