Assay Detail
Functional
CHEMBL654531
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Cytotoxic activity on paclitaxel-resistant CHO-TAX 5-6 cell line expressing mutated tubulin
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-TAX 5-6 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.15 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423394 | — | — | 1 | 6.16 |
| CHEMBL146303 | — | — | 1 | 5.51 |
| CHEMBL149179 | — | — | 1 | 5.44 |
| CHEMBL357489 | — | — | 1 | 5.21 |
| CHEMBL149180 | — | — | 1 | 4.28 |
| CHEMBL150060 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423394 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL146303 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL149179 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL357489 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL149180 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL150060 | — | IC50 | = | 54000.0 | nM | 4.27 |