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Assay Detail

CHEMBL654540

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was tested in vitro for its ability to displace [3H]PN-200-110 from Calcium Channel in rat brain membranes.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Brain
Subcellular Brain membranes
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Isosteric replacement in a series of -substituted monophosphonate calcium antagonists
Poindexter GS, Foley MA, Macdonald JE, George Sarmiento J, Bryson C, Goggins GD, Cavanagh RL, Buyniski JP
Bioorg Med Chem Lett (1993) 3 : 2817 -2820
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 7.36 9.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL193 NIFEDIPINE 4.0 1 9.28
CHEMBL2103776 BELFOSDIL 2.0 1 7.64
CHEMBL408359 1 7.29
CHEMBL97056 1 7.26
CHEMBL94941 1 6.42
CHEMBL327652 1 6.25
CHEMBL318686 1 -
CHEMBL97413 1 -
CHEMBL93239 1 -
CHEMBL317810 1 -
CHEMBL319161 1 -
CHEMBL96166 1 -
CHEMBL330392 1 -
CHEMBL94985 1 -
CHEMBL39516 FOSTEDIL 2.0 1 -
CHEMBL328215 1 -
CHEMBL94776 1 -
CHEMBL95331 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL193 NIFEDIPINE Ki = 0.53 nM 9.28
CHEMBL2103776 BELFOSDIL Ki = 23.0 nM 7.64
CHEMBL408359 Ki = 51.0 nM 7.29
CHEMBL97056 Ki = 55.0 nM 7.26
CHEMBL94941 Ki = 385.0 nM 6.42
CHEMBL327652 Ki = 560.0 nM 6.25
CHEMBL318686 Ki > 1000.0 nM -
CHEMBL97413 Ki > 1000.0 nM -
CHEMBL93239 Ki > 1000.0 nM -
CHEMBL317810 Ki > 1000.0 nM -
CHEMBL319161 Ki > 1000.0 nM -
CHEMBL96166 Ki > 1000.0 nM -
CHEMBL330392 Ki > 1000.0 nM -
CHEMBL94985 Ki > 1000.0 nM -
CHEMBL39516 FOSTEDIL Ki - nM -
CHEMBL328215 Ki > 1000.0 nM -
CHEMBL94776 Ki > 1000.0 nM -
CHEMBL95331 Ki > 1000.0 nM -