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Assay Detail

CHEMBL654570

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of L-type calcium channel subunits alpha1C, beta1b, and alpha2-delta subunits expressed in Human embryonic kidney tsa-201 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Unique structure-activity relationship for 4-isoxazolyl-1,4-dihydropyridines.
Zamponi GW, Stotz SC, Staples RJ, Andro TM, Nelson JK, Hulubei V, Blumenfeld A, Natale NR.
J Med Chem (2003) 46 : 87 -96
PubMed 12502362 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.66 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL369670 1 6.89
CHEMBL104455 1 6.33
CHEMBL317651 1 5.93
CHEMBL176656 1 5.88
CHEMBL173057 1 5.80
CHEMBL173463 1 5.76
CHEMBL323782 1 5.75
CHEMBL366518 1 5.70
CHEMBL173168 1 5.57
CHEMBL172550 1 5.16
CHEMBL74944 1 5.09
CHEMBL173722 1 5.01
CHEMBL174827 1 4.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL369670 IC50 = 130.0 nM 6.89
CHEMBL104455 IC50 = 470.0 nM 6.33
CHEMBL317651 IC50 = 1180.0 nM 5.93
CHEMBL176656 IC50 = 1310.0 nM 5.88
CHEMBL173057 IC50 = 1590.0 nM 5.80
CHEMBL173463 IC50 = 1740.0 nM 5.76
CHEMBL323782 IC50 = 1790.0 nM 5.75
CHEMBL366518 IC50 = 1980.0 nM 5.70
CHEMBL173168 IC50 = 2710.0 nM 5.57
CHEMBL172550 IC50 = 6860.0 nM 5.16
CHEMBL74944 IC50 = 8100.0 nM 5.09
CHEMBL173722 IC50 = 9680.0 nM 5.01
CHEMBL174827 IC50 = 17170.0 nM 4.76