Assay Detail
Binding
CHEMBL654581
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Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Nicotinamide ethers: novel inhibitors of calcium-independent phosphodiesterase and [3H]rolipram binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.66 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL171141 | — | — | 1 | 6.66 |
| CHEMBL354430 | — | — | 1 | 6.27 |
| CHEMBL170122 | — | — | 1 | 6.14 |
| CHEMBL168005 | — | — | 1 | 5.85 |
| CHEMBL171394 | — | — | 1 | 5.75 |
| CHEMBL168418 | — | — | 1 | 5.75 |
| CHEMBL88990 | NITRAQUAZONE | 2.0 | 1 | 5.72 |
| CHEMBL352351 | — | — | 1 | 5.66 |
| CHEMBL352655 | — | — | 1 | 5.66 |
| CHEMBL423073 | — | — | 1 | 5.60 |
| CHEMBL169003 | — | — | 1 | 5.54 |
| CHEMBL169474 | — | — | 1 | 5.51 |
| CHEMBL353878 | — | — | 1 | 5.51 |
| CHEMBL169911 | — | — | 1 | 5.40 |
| CHEMBL168121 | — | — | 1 | 5.19 |
| CHEMBL169269 | — | — | 1 | 5.01 |
| CHEMBL169676 | — | — | 1 | 5.00 |
| CHEMBL353471 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL171141 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL354430 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL170122 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL168005 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL171394 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL168418 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL88990 | NITRAQUAZONE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL352351 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL352655 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL423073 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL169003 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL169474 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL353878 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL169911 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL168121 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL169269 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL169676 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL353471 | — | IC50 | > | 10000.0 | nM | - |