Assay Detail
Functional
CHEMBL654667
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Induced beta-casein protein expression in the CHO-hIR cell line
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-hIR |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro characterization of 1-(4-aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic acid derivatives. A new class of selective GSK-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.76 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325353 | — | — | 1 | 5.34 |
| CHEMBL326705 | — | — | 1 | 4.96 |
| CHEMBL322970 | — | — | 1 | 4.51 |
| CHEMBL113168 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325353 | — | EC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL326705 | — | EC50 | = | 11050.0 | nM | 4.96 |
| CHEMBL322970 | — | EC50 | = | 30620.0 | nM | 4.51 |
| CHEMBL113168 | — | EC50 | = | 57530.0 | nM | 4.24 |