Assay Detail
Binding
CHEMBL654704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of purified mammalian brain calcium [Ca(2+)]/Calmodulin dependent kinase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.68 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.40 |
| CHEMBL311543 | — | — | 1 | 5.66 |
| CHEMBL316239 | — | — | 1 | 5.57 |
| CHEMBL328229 | — | — | 1 | 5.36 |
| CHEMBL419866 | — | — | 1 | 5.28 |
| CHEMBL292495 | — | — | 1 | 5.22 |
| CHEMBL315389 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL311543 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL316239 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL328229 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL419866 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL292495 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL315389 | — | IC50 | = | 56000.0 | nM | 4.25 |