Assay Detail
Functional
CHEMBL654811
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Synergistic antiviral activity with AZT (DDI), against HIV-IIIB in C8166 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.40 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105916 | — | — | 1 | 8.70 |
| CHEMBL107535 | — | — | 1 | 7.30 |
| CHEMBL418812 | — | — | 1 | 7.24 |
| CHEMBL320557 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105916 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL107535 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL418812 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL320557 | — | EC50 | = | 460.0 | nM | 6.34 |