Assay Detail
Functional
CHEMBL654821
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration which results in 50% survival of uninfected untreated control C8166 cells (cytotoxicity of the compound)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.64 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110091 | — | — | 1 | 5.16 |
| CHEMBL107535 | — | — | 1 | 4.96 |
| CHEMBL418812 | — | — | 1 | 4.82 |
| CHEMBL322698 | — | — | 1 | 4.75 |
| CHEMBL107099 | — | — | 1 | 4.68 |
| CHEMBL320557 | — | — | 1 | 4.06 |
| CHEMBL105976 | — | — | 1 | 4.03 |
| CHEMBL105916 | — | — | 1 | - |
| CHEMBL418833 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110091 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL107535 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL418812 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL322698 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL107099 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL320557 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL105976 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL105916 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL418833 | — | IC50 | = | 125000.0 | nM | - |